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Tablet Binding Agent HPMC Hypromellose E464 PH Stable

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Tablet Binding Agent HPMC Hypromellose E464 PH Stable

Tablet Binding Agent HPMC Hypromellose E464 PH Stable
Tablet Binding Agent HPMC Hypromellose E464 PH Stable

Large Image :  Tablet Binding Agent HPMC Hypromellose E464 PH Stable

Product Details:
Place of Origin: China
Brand Name: Honest
Model Number: E5 E15 E4M K100M
Payment & Shipping Terms:
Minimum Order Quantity: 500kgs
Packaging Details: 25kg/Drum
Delivery Time: 10-15days
Payment Terms: L/C, T/T, Western Union
Supply Ability: 500000KGS/Month

Tablet Binding Agent HPMC Hypromellose E464 PH Stable

Description
Appearance: White Or Yellowish Powder Product Name: E5 HPMC Hypromellose
Raw Material: Refined Cotton Application: Thickener, Emulsifier, Film-former, Binder, Dispersing Agent, Protective Colloids
Advantage: Good Water Retention, Stable Sample: 200g Free Sample Provide
High Light:

PH stable hpmc hypromellose E64

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Refined Cotton E5 hpmc hypromellose

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refined cotton hypromellose e464

  Tablet Binding Agent HPMC Hypromellose E5, E15, E50, E4m, K4m, K100, K100m Equal to Methocel

 

【Introduction

Name: Hypromellose or Hydroxypropyl Methyl Cellulose(HPMC,Hypromellose)

Appearance and properties: White or almost white fibrous or granular powder

E Number:E464

CAS NO:9004-65-3

Molecular Formula: [C6H7O2(OH)x-m-n (OCH3 )m (OCH2CH (OH)CH3 )n]x

 

 

Tablet Binding Agent HPMC Hypromellose E464 PH Stable 0

 

Characteristics

 

HPMC, also known as hypromellose, is one of the non-ionic cellulose mixed ethers. It is a semi-synthetic, inactive, viscoelastic polymer, often used as a lubricant in ophthalmology, or as an excipient or excipient in oral medicine.HPMC is used as a precipitation inhibitor for solid dispersions in spray drying or hot melt extrusion formulations.

 

 

Properties

1.Cohesiveness (Binding property) :Hypromellose or HPMC , as a high performance binder , can also be used for molding food and medicine .

2. PH stability :The viscosity of an aqueous solution of HPMC is hardly affected by acid or alkali , and the product can develop an original viscosity in the range of 3 . 0~11 . 0 . Therefore , the solution viscosity tends to keep stable during prolonged storage ..

 

3. Film forming :Hypromellose or HPMC provides a strong , flexible and transparent film having a good barrier property against oil and grease . In food application , this property is often utilized for water retention and oil adsorption .

 

4. Water retention :Hypromellose or HPMC is a high effective water retention agent . Its pharmaceutical grade product can be widely used in food , cosmetics and many other fields .

5. Solubility: soluble in water and some solvents, such as ethanol/water, propanol/water in appropriate proportions. The aqueous solution has surface activity. High transparency and stable performance. Different specifications of products have different gel temperatures, and solubility changes with viscosity. The lower the viscosity, the greater the solubility. Different specifications of Hypromellose or HPMC have certain differences in performance. The dissolution of Hypromellose or HPMC in water is not affected by pH.

 

6.Hypromellose or HPMC also has the characteristics of thickening ability, salt resistance, low ash powder, pH stability, water retention, dimensional stability, excellent film-forming properties, and extensive enzyme resistance, dispersibility, and adhesion.

 

Technical requirements

 

1.Appearance: white to yellowish powder 

 

2.Viscosity Specification as below

 

Level Specific range (2% Sol.),mPa.s Level Specific range (2% Sol.),mPa.s
5 4~6 4000 3000~5600
15 12~18 8000 6000~9000
25 20~30 10,000 9000~12000
50 40~60 15,000 12000~18000
100 80~120 20,000 18000~30000
400 300~500 40,000 30000~50000
800 600~900 100,000 85000~130000
1500 1000~2000 200,000 ≥180000

 

3.Techinical Specifications:

 

Items

 

Specifications
  HPMC
  F E J K
Loss on drying,% 5.0 max
Residue on ignition,% 1.5 max
Heavy metals, ppm 20 max
Arsenic, ppm 3 max
pH 5.0~8.0
Bacterium 1000cfu/gram Max
Mold 100cfu/gram Max
Viscosity(2% solution), mPa.s In accordance with the viscosity specification as shown in table 2.

 

Note: Any other special requirement for the product can be satisfied through the negotiation.

 

Application

Hypromellose (HPMC) is a multi-purpose pharmaceutical excipient.

 

The high viscosity specification is widely used in the sustained and controlled release system of hydrophilic gel matrix. The low-viscosity grade is used as the main shell material in tablet coating and non-gelatin capsule formulations, and is also a commonly used binder in wet granulation.

 

Selection guide of products for pharmaceutical:

 

Usage Applicable type of the product

Typical Use

Level

Bulk Laxative K-4000,K-100,000 3-30%
Creams, Gels, and Ointments E-4000,F-4000,K-4000 1-5%
Ophthalmic Preparations E-4000 01 .-0 . 5%
Eye drops preparations F-4000, K-4000 0 . 1-0 . 5%
Suspending agent E-4000, K-4000 1-2%
Antacids E-4000,K-4000,K-15000,F-4000 1-2%
Tablets binder E-5, F-50, K- 100 0 . 5-5%
Conventional Tablet Coating E-5,E-15 0 . 5-5%
Conventional Wet Granulation E-5,E-15 2-6%
Controlled Release Coatings E-5,E-15 3-20%
Tablet coatings E-5, E- 15, E-50 0 . 5-5%

Controlled Release Matrix

Tablets

K- 100,000,K- 15,000,K-4000,E-4000

 

20-55%

 

 

Packaging

Hypromellose or HPMC is packed in polyethylene bag enclosed in composite fiberboard drum . The standard packing is 25kg/drum 

N.W:25KG/drum
G.W:27.5/drum
Loading Quantity in 20'FCL With Pallet: 9Tons

Packing
Tablet Binding Agent HPMC Hypromellose E464 PH Stable 1

 


 
 

Transportation and Storage

 

The product should be kept in the original bag and stored in the dry and clean place far away from the source of heat and not put together with other chemicals .

The direct addition of the product to water causes the formation of lumps . Lumping results from incomplete wetting of the individual powder particles . Only the powder in contact with water dissolves and the formed gelatinous membrane prevents the remaining powder from dissolving , causing a delay in the dissolution time . The following three methods are recommended for dissolution without forming lumps . The most convenient method should be chosen according to the purpose of your application.

 

 

 

Contact Details
Shanghai Honest Chem. Co., Ltd.

Contact Person: admin

Tel: +8618516512831

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