Pharma grade HPMC

Short Description:

Hydroxypropyl methyl cellulose (HPMC; CAS No. 9004-65-3) is an odorless and tasteless, white to slightly off-white, fibrous or granular, free-flowing powder that is a synthetic modification of the natural polymer, cellulose. Hydroxypropyl methyl cellulose has become one of the largest pharmaceutical excipients because it possesses the advantages of other complementary makings don’t have. Advantages of HPMC 1. Chemical inertness HPMC is a kind of non-ionic cellulose ether, whose solution...


  • Min.Order Quantity: 20KG(Ethyl Cellulose)
  • Supply Ability: 30000 ton/year(Hydropropyl Methyl Cellulose);5000 ton/year(Hydroxyethyl Cellulose);30000 ton/year(Carboxymethyl Cellulose);600 ton/year(Ethyl Cellulose);10000 ton/year self-leveling compound master batch
  • Port: Shanghai
  • Payment Terms: L/C,D/A,D/P,T/T
  • Product Detail

    Product Tags

    Hydroxypropyl methyl cellulose (HPMC; CAS No. 9004-65-3) is an odorless and tasteless, white to slightly off-white, fibrous or granular, free-flowing powder that is a synthetic modification of the natural polymer, cellulose.

    Hydroxypropyl methyl cellulose has become one of the largest pharmaceutical excipients because it possesses the advantages of other complementary makings don’t have.

    Advantages of HPMC

    1. Chemical inertness

    HPMC is a kind of non-ionic cellulose ether, whose solution doesn’t take ionic charge and don’t react with metal salt or ionic organics. So there is no reaction between it and other materials during the preparation.

    2. Stability

    it is relatively stable in acid and alkali, and providing good viscosity stability between pH3 ~ 11 during long-term storage. Aqueous solutions are comparatively enzyme-resistant. Preparation materials using HPMC, its quality and stability is better than the traditional materials (dextrin, starch, etc.).

    3. Safety

    HPMC is generally regarded as a nontoxic and non-irritating material, The WHO has not specified an acceptable daily intake for HPMC since the levels consumed were not considered to represent a hazard to health.

    4. Viscosity can be regulatory

    The derivatives of different viscosity of HPMC can complex with each other according to the different proportion. Its viscosity can be change according to certain rules, and has a good linear relationship, so it can be chosen accord- ing to requirements in terms of proportion.

    5. Metabolism inertia

    HPMC is not absorbed and metabolized in the body, and cannot give heat, so it is a safe medicinal preparation ma- terial.

    6. Soluble in cold water

    Soluble in cold water under 40 ℃ or 70% ethanol, practically insoluble in hot water but gelation.

    Technical requirements

    1. Appearance:White to light yellow powder or grains.
    2. Specifications:

    Table 1. Specifications of MC&HPMC

    Items

    Specifications

    MC

    HPMC

    MA

    F

    E

    J

    K

    Loss on drying,%

    5.0 max

    Residue on ignition,%

    1.5 max

    Heavy metals, ppm

    20 max

    Arsenic, ppm

    3 max

    pH

    5.0~8.0

    Viscosity(2% solution), mPa.s

    In accordance with the viscosity specification as shown in table 2.

    3. Viscosity specification

    Table 2. Viscosity specification of MC&HPMC

    Level

    Specific range (2% Sol.),mPa.s

    Level

    Specific range (2% Sol.),mPa.s

    5

    4~6

    4000

    3000~5600

    15

    12~18

    8000

    6000~9000

    25

    20~30

    10,000

    9000~12000

    50

    40~60

    15,000

    12000~18000

    100

    80~120

    20,000

    18000~30000

    400

    300~500

    40,000

    30000~50000

    800

    600~900

    100,000

    85000~130000

    1500

    1000~2000

    200,000

    ≥180000

    NoteThe viscosity can be adjusted according to the special requirements of the customers.

    Selection guide of products for pharmaceutical

    Usage Applicable type of the product Typical Use Level
    Bulk Laxative MA-4000,K-4000,K-100,000 3-30%
    Creams, Gels, and Ointments MA-4000,E-4000,F-4000,K-4000 1-5%
    Ophthalmic Preparations E-4000 01.-0.5%
    Eye drops preparations MA-4000, F-4000, K-4000 0.1-0.5%
    Suspending agent MA-4000, E-4000, K-4000 1-2%
    Antacids MA-1500,MA-4000,E-4000,K-4000,K-15000,F-4000 1-2%
    Tablets binder MA-15, E-5, F-50, K-100 0.5-5%
    Conventional Tablet Coating E-5,E-15 0.5-5%
    Conventional Wet Granulation E-5,E-15 2-6%
    Controlled Release Coatings E-5,E-15 3-20%
    Tablet coatings E-5, E-15, E-50 0.5-5%
    Controlled Release Matrix Tablets K-100,000,K-15,000,K-4000,E-4000 20-55%

     

    Packaging

    The product is packed in polyethylene bag enclosed in composite fiberboard drum or paper bag. The net weight is 25 kg/drum or 25 kg/bag.

    The product should be kept in the original bag and stored in the dry and clean place far away from the source of heat and not put together with other chemicals.

     








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