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Pharmaceutical Grade HPMC Hypromellose for Tablets binder

Basic Information
Place of Origin: China
Brand Name: Honest
Model Number: E5 E15 E4M K100M
Minimum Order Quantity: 500kgs
Packaging Details: 25kg/Drum
Delivery Time: 10-15days
Payment Terms: L/C, T/T, Western Union
Supply Ability: 500000KGS/Month
Detail Information
Product Name: Pharmaceutical Grade HPMC Hypromellose For Tablets Binder Appearance: White Or Yellowish Powder
Raw Material: Refined Cotton Application: Thickener, Emulsifier, Film-former, Binder, Dispersing Agent, Protective Colloids
Advantage: Good Water Retention, Stable Sample: 200g Free Sample Provide
High Light:

25 kg drum Pharmaceutical Grade HPMC Hypromellose

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Honest 25 kg drum cas no 9004 65 3

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9004 65 3 White powder HPMC Hypromellose


Product Description

Pharmaceutical Grade Hydroxypropyl Methyl Cellulose Hypromellose CAS NO 9004-65-3

 

Introduction

Name: Hypromellose or Hydroxypropyl Methyl Cellulose

Appearance and properties: white or almost white fibrous or granular powder 

Abbreviation: HPMC

Molecular Formula: [C6H7O2(OH)x-m-n (OCH3 )m (OCH2CH (OH)CH3 )n]x

CAS: 9004-65-3

 

Pharmaceutical Grade HPMC Hypromellose for Tablets binder 0

 

Characteristics

 

Hypromellose or Hydroxypropyl methyl cellulose (HPMC; CAS No. 9004-65-3) is an odorless and tasteless, white to slightly off-white, fibrous or granular, free-flowing powder that is a synthetic modification of the natural polymer, cellulose.

 

Properties

1. Cohesiveness (Binding property) :Hypromellose or HPMC , as a high performance binder , can also be used for molding food and medicine .

2. Resistance to salting out :Hypromellose or HPMC is a nonionic cellulose ether and it is not a polyelectrolyte . The aqueous solution of HPMC is comparatively stable even in the presence of metal salts or organic electrolytes . However , when the concentration of electrolytes exceeds a certain limit , gelation and precipitation may result .

3. pH stability :The viscosity of an aqueous solution of Hypromellose or HPMC is hardly affected by acid or alkali , and the product can develop an original viscosity in the range of 3 . 0~11 . 0 . Therefore , the solution viscosity tends to keep stable during prolonged storage .

4. Surface activity :An aqueous solution of Hypromellose or HPMC has a high surface activity and functions as a protective colloid agent , emulsion stabilizer and dispersant .

 

5. Film forming :Hypromellose or HPMC provides a strong , flexible and transparent film having a good barrier property against oil and grease . In food application , this property is often utilized for water retention and oil adsorption .

 

6. Water retention :Hypromellose or HPMC is a high effective water retention agent . Its pharmaceutical grade product can be widely used in food , cosmetics and many other fields .

7.  Apparent density: 0.25-0.70g/cm (usually around 0.5g/cm), specific gravity 1.26-1.31.
8. Discoloration temperature: 190-200℃
9. Surface tension: 42-56dyn/cm for 2% aqueous solution.

 

Technical requirements

 

1. Appearance: white to yellowish powder or grains.

 

2. Viscosity Specification

 

Pharmaceutical Grade HPMC Hypromellose for Tablets binder 1

 

3. Specifications:

Pharmaceutical Grade HPMC Hypromellose for Tablets binder 2

 

 

Note: Any other special requirement for the product can be satisfied through the negotiation.

 

Application

Hypromellose or HPMC, a multipurpose additive for pharmaceutical, can be functioned as thickener, dispersion, emulsifier, film forming agent, etc . It is used in tablets for dressing and binding to improve solubility of the drugs and reinforce tablets’ water prevention function . It can also be utilized as mixed suspending agent, additive for eye drops, sustained-release agent, and so on .

 

Selection guide of products for pharmaceutical:

 

Usage Applicable type of the product

Typical Use

Level

Bulk Laxative K-4000,K-100,000 3-30%
Creams, Gels, and Ointments E-4000,F-4000,K-4000 1-5%
Ophthalmic Preparations E-4000 01 .-0 . 5%
Eye drops preparations F-4000, K-4000 0 . 1-0 . 5%
Suspending agent E-4000, K-4000 1-2%
Antacids E-4000,K-4000,K-15000,F-4000 1-2%
Tablets binder E-5, F-50, K- 100 0 . 5-5%
Conventional Tablet Coating E-5,E-15 0 . 5-5%
Conventional Wet Granulation E-5,E-15 2-6%
Controlled Release Coatings E-5,E-15 3-20%
Tablet coatings E-5, E- 15, E-50 0 . 5-5%

Controlled Release Matrix

Tablets

K- 100,000,K- 15,000,K-4000,E-4000

 

20-55%

 

 

Packaging

Hypromellose or HPMC is packed in polyethylene bag enclosed in composite fiberboard drum . The net weight is 25 kg/drum and gross weight is 27.5kg/drum 

 

Transportation and Storage

 

The product should be kept in the original bag and stored in the dry and clean place far away from the source of heat and not put together with other chemicals .

The direct addition of the product to water causes the formation of lumps . Lumping results from incomplete wetting of the individual powder particles . Only the powder in contact with water dissolves and the formed gelatinous membrane prevents the remaining powder from dissolving , causing a delay in the dissolution time . 

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