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Product Details:
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| Product Name: | 9004 65 3 HPMC Pharma | Appearance: | White Or Yellowish Powder |
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| Raw Material: | Refined Cotton | Application: | Controll Release,Coating,Granulation,Solubility Enhancement,Spray Dried Dispersions,Direct Compression Tableting |
| Properties: | Film Formation，Low Taste And Odor，Protective Colloidal Action，Metabolic Inertness，Water Solubility，Binding | Sample: | 200g Free Sample Provide |
| Standard: | USP EP JP | ||
| High Light: | Hydroxypropyl Methyl Cellulose Polymer,JP Hydroxypropyl Methyl Cellulose,Pharma Hydroxypropyl Methylcellulose Powder |
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USP EP JP Hydroxypropyl Methyl Cellulose HPMC Pharma grade
Hydroxypropyl Methyl Cellulose is water-soluble polymers derived from cellulose. Hydroxypropyl Methyl Cellulose available in different grades to address a wide range of applications including granulation, tablet coatings controlled release, drug layering, eye drops preparations, suspending agent, vegetarian hard-shell capsules and amorphous drug stabilization.
【Introduction】
Name: Hydroxypropyl Methyl Cellulose (HPMC,Hypromellose)
Appearance and properties: White or almost white fibrous or granular powder
CAS NO:9004-65-3
Molecular Formula: [C6H7O2(OH)x-m-n (OCH3 )m (OCH2CH (OH)CH3 )n]x
【Characteristics】
Hydroxypropyl methyl cellulose (HPMC) or hypromellose, is a cellulose-based polymer for film coating, wet granulation, and hard capsule manufacturing. It is practically insoluble in hot water, acetone, anhydrous ethanol, and toluene and dissolves in cold water, resulting in a colloidal solution.
【Technical requirements】
1. Appearance: white to yellowish powder
2. Viscosity Specification as below
| Level | Specific range (2% ,mPa s) | Level | Specific range (2% ,mPas) | ||||
| 5 | 4~6 | 4000 | 3000~5600 | ||||
| 15 | 12~18 | 8000 | 6000~9000 | ||||
| 25 | 20~30 | 10,000 | 9000~12000 | ||||
| 50 | 40~60 | 15,000 | 12000~18000 | ||||
| 100 | 80~120 | 20,000 | 18000~30000 | ||||
| 400 | 300~500 | 40,000 | 30000~50000 | ||||
| 800 | 600~900 | 100,000 | 85000~130000 | ||||
| 1500 | 1000~2000 | 200,000 | ≥180000 | ||||
3. Techinical Specifications:
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Specifications | |||
| HPMC | ||||
| F | E | J | K | |
| Loss on drying,% | 5 . 0 max | |||
| Residue on ignition,% | 1 . 5 max | |||
| Heavy metals, ppm | 20 max | |||
| Arsenic, ppm | 3 max | |||
| pH | 5 . 0~8 .0 | |||
| Bacterium | 1000cfu/gram Max | |||
| Mold | 100cfu/gram Max | |||
| Viscosity(2% solution), mPa .s | In accordance with the viscosity specification as shown in table 2 . | |||
【Application】
Selection guide of products for pharmaceutical:
| Usage | Applicable type of the product |
Typical Use |
| Bulk Laxative | K-4000,K-100,000 | 3-30% |
| Creams, Gels, and Ointments | E-4000,F-4000,K-4000 | 1-5% |
| Ophthalmic Preparations | E-4000 | 01 .-0 . 5% |
| Eye drops preparations | F-4000, K-4000 | 0 . 1-0 . 5% |
| Suspending agent | E-4000, K-4000 | 1-2% |
| Antacids | E-4000,K-4000,K-15000,F-4000 | 1-2% |
| Tablets binder | E-5, F-50, K- 100 | 0 . 5-5% |
| Conventional Tablet Coating | E-5,E-15 | 0 . 5-5% |
| Conventional Wet Granulation | E-5,E-15 | 2-6% |
| Controlled Release Coatings | E-5,E-15 | 3-20% |
| Tablet coatings | E-5, E- 15, E-50 | 0 . 5-5% |
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Controlled Release Matrix |
K- 100,000,K- 15,000,K-4000,E-4000 |
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【Packaging】
HPMC pharma grade is packed in 2 layer LDPE bag and sealed in the Drum, it is very safe to store and transport. the standard packing is 25kg/drum
【Transportation and Storage】
The product should be kept in the original bag and stored in the dry and clean place far away from the source of heat and not put together with other chemicals .
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